Mocking white people who now depend on government assistance because of the pandemic after Black people have been long stereotyped as being on welfare, Chappelle compared their condition to a former president's perception of Black people.
"Remember what Ronald Reagan used to say about Black people? 'Welfare people, drug addicts'? Who does that sound like now?" he said. "Stimulus checks, heroin. The rest of the country is trying to move forward and these white n***as keep holding us back."
While dozens of white people still refuse to wear masks, the SNL host reminded them about the metaphoric mask he has to wear throughout his life.
"Try wearing the mask I've been wearing all these years," he said. "I can't even tell something true unless it has a punch line behind it."
But Chappelle is willing to help white people survive the pandemic.
"You guys aren't ready for this," he said. "You don't know how to survive yourselves. Black people are the only ones that know how to survive this. Come, hurry quick. Come get your n***a lessons."
To the white people who still aren't willing to learn, Chappelle tried to make his point more clear with an example from the segregation era.
"You need us. You need our eyes to save you from yourselves," the 47-year-old said. "Remember when white people and Black people couldn't be together? It was just white people only in the club dancing. You ever see that old footage? How did they look?"
The SNL performance conveniently fell on the same day as Joe Biden and Kamala Harris' victory against Donald Trump in the presidential race, giving Chappelle more material for the show.
"Now, Trump is gone," the comedian said. "A lot of people don't like him, but I thought the guy was at least an optimist. I'm not as optimistic as he was. I look at it like 'there is bad people on both sides."
But the 47-year-old stopped himself short as he failed in his attempt to understand Trump, who is remembered for describing some KKK members as good people. As it turned out, the soon-to-be former president may have been stealing Chappelle's materials in the past four years.
"He called the coronavirus the kung flu," the SNL host said. "I said you racist, hilarious, son of a b**ch. I'm supposed to say that, not you. It's wrong when you say it."
Chappelle finished the show on a somber note.
"For the first time in the history of America, the life expectancy of white people is dropping because of heroine, because of suicide. All this white people out there that feel that anguish, that pain — they're mad because nobody cares," the comedian said. "I know how that feels."