The trailer for the fourth season of Netflix’s Sex Education is here, and it confirms that this will be the show’s final run.

Here’s the Season 4 longline:

Following the closure of Moordale Secondary, Otis and Eric now face a new frontier – their first day at Cavendish Sixth Form College. Otis is nervous about setting up his new clinic, whilst Eric is praying they won’t be losers again. But Cavendish is a culture shock for all the Moordale students – they thought they were progressive but this new college is another level. There’s daily yoga in the communal garden, a strong sustainability vibe and a group of kids who are popular for being… kind?! Viv is totally thrown by the college’s student-led, non-competitive approach, while Jackson is still struggling to get over Cal. Aimee tries something new by taking an Art A-Level and Adam grapples with whether mainstream education is for him. Over in the US, Maeve is living her dream at prestigious Wallace University, being taught by cult author Thomas Molloy. Otis is pining after her, whilst adjusting to not being an only child at home, or the only therapist on campus…

The Season 4 cast will be led by:

Asa Butterfield as Otis Milburn, alongside Gillian Anderson, Ncuti Gatwa, Aimee-Lou Wood, Emma Mackey, Connor Swindells, Kedar Williams-Stirling, Mimi Keene, George Robinson, Chinenye Ezeudu, Dua Saleh, Alistair Petrie, Samantha Spiro, Jim Howick, Rakhee Thakrar and Daniel Ings.

Jodie Smith-Turner, Dan Levy, and more are set to guest star.

Other guest stars Thaddea Graham (Doctor Who), Lisa McGrillis (Somewhere Boy), Marie Reuther (Kamikaze), comedian Eshaan Akbar and newcomers Felix Mufti, Anthony Lexa, Alexandra James, Reda Elazouar, Bella Maclean and Imani Yahshua.

Watch the official teaser trailer below:

The final season of Sex Education premieres September 21 on Netflix.